Novel Lipidated Compounds for Delivery and Function.

Tarakkad Krishnaji, Subrahmanian.

Abstract: Cells regulate gene activity by post-transcriptional silencing of the genes using small double stranded RNAs (dsRNAs). This phenomenon is called RNA interference (RNAi). In mammalian cells, RNA duplexes, termed as short interfering RNAs (siRNAs), bind to cognate mRNA sequences and based on complementarity, repress translation or cleave mRNA strands. This gene-silencing pathway can be uti... read more

Tufts University. Department of Chemistry.
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ID: tufts:21163
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