Depth Discrimination of Optical Inhomogeneities in a Liquid Phantom using a 2D Planar Scanning Diffuse Optical Imaging System.
Weliwitigoda, Geethika.
2012
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Abstract: Near
infrared diffuse optical imaging has been a subject of much research for breast cancer
screening purposes. In this study, we are testing the performance of a method to
discriminate the depths of inhomogeneities in a liquid phantom using a 2D planar
scanning frequency domain diffuse optical imaging system. A specific subject of interest
is the calibration curves which are used ... read moreto calibrate the off-axis shift between two
detectors and a depth value. In particular, we are assessing how accurately the
simulation software replicates the liquid phantom for different variations in optical
properties, source-detector configuration, and geometry. We also describe the data
processing that is necessary before the depth calculations can be executed and the noise
characterization of the liquid phantom. It was found that for the calibration curves
used for the experiments under calculated black rod inhomogeneities of shallower and
middle depths (~± 8 mm for normalized depth (z/D) < .6). In contrast, the
accuracy was significantly higher for deeper depths (~± 3 mm for z/D > .6) .
Also, we found that the depth calculation is not affected by the angle of the rod
structure in the x-y plane, nor the angle of the rod structure in depth direction.
Lastly, we developed a calibration curve based on experimental data and compared it to
that derived through simulation. It was found that the experimental calibration curve
related off-axis shift to depth more accurately than the simulation-derived calibration
curves.
Thesis (M.S.)--Tufts University, 2012.
Submitted to the Dept. of Biomedical Engineering.
Advisor: Sergio Fantini.
Committee: Eric Miller, and Mark Cronin-Golomb.
Keywords: Medical imaging and radiology, and Biomedical engineering.read less - ID:
- qf85np45w
- Component ID:
- tufts:21158
- To Cite:
- TARC Citation Guide EndNote
