The role of CRF type-1 receptors in the VTA and DRN in excessive alcohol drinking in rats and mice.
Hwa, Lara.
2011
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Abstract: The dysregulation of brain stress systems, specifically
extrahypothalamic action of corticotropin-releasing factor (CRF) via the type-1 receptor
(CRF-R1), is thought to mediate escalated, alcohol drinking. The current study modeled
excessive drinking in rodents by offering adult male Long-Evans rats and C57BL/6J mice a
choice of 20% ethanol or water for 24 hours intermittently throughout ... read morethe week. After
escalated baseline drinking was established, animals received several doses of a CRF-R1
antagonist into either the ventral tegmental area (VTA) or the dorsal raphé nucleus (DRN)
aiming to decrease alcohol drinking. CP-154,526 selectively reduced ethanol drinking in the
VTA in all animals whereas only the high alcohol preferring animals, the mice and
high-preferring rats, showed this decrease in the DRN. Since CP-154,526 reduced water
intake in the DRN, we demonstrated a differentiation between brain sites in how selective
CRF-R1 antagonism can act to suppress elevated ethanol drinking in some individuals but not
others.
Thesis (M.S.)--Tufts University, 2011.
Submitted to the Dept. of Psychology.
Advisor: Klaus Miczek.
Committee: Joseph DeBold, and Michael Romero.
Keywords: Physiological psychology, and Behavioral sciences.read less - ID:
- ks65hq42x
- Component ID:
- tufts:20863
- To Cite:
- TARC Citation Guide EndNote
