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Abstract: A series
of experiments were carried out to address the lack in therapeutic cell/drug delivery
devices capable of targeting moving tissues and organs. First the in vivo angiogenic
response to dual growth factor delivery by an in situ polymerizing hyaluronic acid
hydrogel was investigated via direct elicited microvessel counts. Second a HA-silk
biocomposite was fabricated, physically ... read morecharacterized and its potential use as an
implantable drug or cell delivery vehicle established. Finally, hydrogel composition was
optimized for survival and growth of cells encapsulated prior to hydrogel
polymerization. The combination these experiments should lead to the development of a
securable non-tissue site specific biocomposite capable of sustained cell growth and
drug delivery as well as fostering an angiogenic response in and around the implant
site.
Thesis (M.S.)--Tufts University,
2011.
Submitted to the Dept. of Biomedical
Engineering.
Advisor: Robert
Peattie.
Committee: David Kaplan, and Barry
Trimmer.
Keyword: Biomedical
engineering.read less
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