Metabolic Studies of Hepatic Response to Diabetes Drugs.

Carson, Katherine.

Abstract: A major concern in drug development is the potential for chemical injury to the liver. Drugs account for 1/3~1/2 of acute liver failures, yet underlying toxicity mechanisms are poorly understood. Adverse reactions are often detected too late, as with troglitazone, an antidiabetic drug introduced in 1997 and withdrawn in 2000 after several cases of liver failure. Predictions are more limi... read more

Tufts University. Department of Chemical and Biological Engineering.
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ID: tufts:20768
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