Prevention of social stress-escalated cocaine self-administration by CRF-R1 antagonist in the rat VTA.

Boyson, Christopher.

Abstract: Intermittent exposure to social defeat stress can induce long-term neural plasticity that may influence escalated cocaine-taking behavior. Stressful encounters can lead to activation of dopamine neurons in the ventral tegmental area (VTA), which are modulated by corticotropin releasing factor (CRF) neurons. The study aims to prevent the effects of intermittently scheduled, brief social d... read more

Tufts University. Department of Psychology.
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ID: tufts:20747
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