The STING of death in T cells: IFN responses and cell death result from activation of T cell STING

Larkin, Bridget.

Abstract: STING, a critical mediator of IFN-I responses, has increasingly been recognized for its importance in a variety of immune responses to intracellular bacterial and viral DNA as well as endogenous DNA involved in tumorigenesis and the development of autoimmune disease. Therapeutically, STING has also been proven to be a potent vaccine adjuvant for model and tumor antigens. Yet, in all of t... read more

Sackler School of Graduate Biomedical Sciences. Department of Immunology.
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ID: tufts:20662
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