The endosomal-associated deubiquitinating enzyme USP8 regulates BACE1 ubiquitination and degradation.

Yeates, Eniola.
2016

Abstract: -site amyloid precursor protein cleaving enzyme (BACE1) is the rate-limiting enzyme in the production of amyloid beta (A), the toxic peptide that accumulates in the brain of subjects affected by Alzheimer's disease. Previous studies have shown that BACE1 is degraded via the lysosomal pathway, BACE1 is ubiquitinated at lysine 501 and that blocking ubiquitination at lysine 501 results in B... read more

Subjects
Sackler School of Graduate Biomedical Sciences. Department of Neuroscience.
Permanent URL
http://hdl.handle.net/10427/011164
ID: tufts:20636
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