Role of hypoxia in the regulation of the microRNA-containing RNA-induced silencing complex.

Wu, Connie.

Abstract: Hypoxia plays a major role in the pathobiology of pulmonary arterial hypertension (PAH), a disease characterized by obstructive remodeling of the small pulmonary arteries (PAs). Acute hypoxia results in the selective constriction of PAs and elevation of pulmonary arterial pressure, while chronic exposure to hypoxia induces structural and functional changes to the pulmonary vasculature. T... read more

Sackler School of Graduate Biomedical Sciences. Department of Biochemistry.
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