Observations and insights from a study of RalGDS in cancer.

Wong, Richard.

Abstract: Ral exchange factors are transducers of Ras activation. These exchange factors target the small GTPases RalA and RalB. Four RalGEFs (RalGDS, Rgl 1, Rgl2/Rlf, and Rgl3) have been identified with the ability to bind Ras through a conserved Ras binding domain. Other Ral exchange (RalGPS1, RalGPS2, and Rgr) factors have also been identified which do not have RBDs and are thought to be activa... read more

Sackler School of Graduate Biomedical Sciences. Department of Biochemistry.
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