3 phosphorylation in autism spectrum disorders and neurosteroid activity.

Vien, Thuy N.
2015

Abstract: Alterations in GABAAR 3 expression and function are linked to autism spectrum disorders (ASDs). Protein kinase C (PKC)-mediated phosphorylation of the 3 subunit on serine residues 408/9 (S408/9) shapes its membrane expression and GABAergic inhibition. To evaluate whether dysregulation of this process was involved in ASDs we assessed 3 phosphorylation in Fmr1 knockout mice, a widely accep... read more

Subjects
Sackler School of Graduate Biomedical Sciences. Department of Pharmacology and Experimental Therapeutics.
Permanent URL
http://hdl.handle.net/10427/011137
ID: tufts:20610
To Cite: DCA Citation Guide