Activation-Induced Deaminase in Early Developing B cells and Toll-like Receptor 8 in the Etiopathology of Murine Systemic Lupus Erythematosus.

Umiker, Benjamin.

Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the presence of pathogenic IgG anti-nuclear antibodies and increased type I interferon (IFN-I) production. Increased granulopoiesis is often observed in human SLE patients; however, the mechanism by which these cells contribute to autoantibody and IFN-I production is unclear. Using 564Igi mice, which model these... read more

Sackler School of Graduate Biomedical Sciences. Department of Immunology.
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ID: tufts:20609
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