Pharmacological Boosting Effect and Inhibitory Mechanism of Cobicistat and Ritonavir on Human Cytochrome P450 Isoforms.

Tran, Timothy.
2016

Abstract: Abstract Pharmacokinetic boosting is the result of one drug increasing another co-administered drug's serum concentration to achieve a therapeutic effect. Here in this study, two protease inhibitor (PI) class drugs used in treatment of HIV that have boosting effects are evaluated for their potency and mechanism of inhibition on cytochrome P450 isoforms. Ritonavir is a widely used pharmac... read more

Subjects
Sackler School of Graduate Biomedical Sciences. Department of Pharmacology and Experimental Therapeutics.
Permanent URL
http://hdl.handle.net/10427/011127
ID: tufts:20600
To Cite: DCA Citation Guide