Wild-derived allele of Tmem173 potentiates an alternate signaling response to cytosolic DNA.Surpris, Guy.
Abstract: The cellular recognition of cytosolic DNA is critical for maintaining homeostasis and to signal warnings to prevent the spread of pathogens such as HSV1 or Listeria. Inborn mutations in the human population determine the susceptibility or ability to clear infection. Mouse models of infectious disease are an invaluable resource for the study of these mechanisms of disease progression. How... read more
- Sackler School of Graduate Biomedical Sciences. Department of Immunology.
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