Dynamics of Mammary Epithelial Cell Differentiation. "What's SLUG Got to Do With It?".

Phillips, Sarah.

Abstract: Perturbations in stem cell activity and differentiation can lead to developmental defects and cancer. How mutations in genes affect these processes are difficult to study in mammals, and often require the creation of transgenic mice. Here, I use a novel approach involving a quantitative model of cell-state transitions in vitro to gain insights into how SLUG/SNAI2, a key developmental tra... read more

Sackler School of Graduate Biomedical Sciences. Department of Genetics.
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ID: tufts:20574
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