Investigation of the molecular mechanisms by which alcohol initiates hepatic injury and promotes carcinogenesis and the prevention of these pathologies through dietary tomato intervention.

Stice, Camilla.

Abstract: Chronic and excessive consumption of alcohol leads to the development of alcoholic liver disease (ALD) and is a major risk factor for hepatocellular carcinoma (HCC). Induction of the cytochrome p450 2E1 (CYP2E1) enzyme and inflammatory responses by alcohol play a role in the pathogenesis of both ALD and HCC. Avoidance of chronic or excessive alcohol intake is the best protection against ... read more

Gerald J. & Dorothy R. Friedman School of Nutrition Science and Policy.
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ID: tufts:20573
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