Study of immune cell signaling modulation by Yersinia protein kinase A (YpkA/YopO).

Sood, Arpana.

Abstract: Bacterial pathogens employ several strategies to dampen host cell immune responses. In this work we studied a secreted effector protein of the Yersinia pseudotuberculosis type-three secretion system (T3SS). We found that Yersinia protein kinase A (YpkA), employs serine-kinase activity to target immune cell signaling and dampen chemotaxis and reactive oxygen species (ROS)-production. Cell... read more

Sackler School of Graduate Biomedical Sciences. Department of Molecular Microbiology.
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ID: tufts:20571
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