Extracellular Hsp90alpha and Hsp70 Increase Activation of MMP-2 in Breast Cancer Migration and Invasion.

Sims, Jessica.

Abstract: The goal of this thesis was to gain a better understanding of extracellular Heat Shock Protein 90&alpha (Hsp90&alpha) and its role in breast cancer migration and invasion through the activation of Matrix Metalloproteinase-2 (MMP-2). This work, which was begun by Brenda Eustace, a previous graduate student in the Jay Lab, initially identified Hsp90&alpha outside of fibrosarcom... read more

Sackler School of Graduate Biomedical Sciences Department of Cell, Molecular and Developmental Biology.
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