Regulation of immunoglobulin diversification pathways by AID in a transgenic mouse model.

Shansab, Maryam.

Abstract: The activation-induced cytidine deaminase (AID) enzyme plays a central role in B-cell diversification such as somatic hypermutation (SHM), immunoglobulin (Ig) V-gene conversion, and class switch recombination (CSR). AID function has also been implicated in chromosomal B-cell translocations between the c-myc oncogene and the immunoglobulin heavy-chain (Igh) locus. The regulatory mechanism... read more

Sackler School of Graduate Biomedical Sciences. Department of Immunology.
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