Molecular and cellular basis for transformation associated with BRCA1-haploinsufficiency.

Sedic, Maja.
2013

Abstract: Individuals with inherited mutations in BRCA1 have a ~ 80% chance of developing breast and ovarian cancer within their lifetimes. Although BRCA1 function appears to be essential for maintaining genomic integrity in all cell types, it is unclear why increased risk of cancer development in individuals with mutations in BRCA1 is restricted to only a select few tissues. Moreover since loss o... read more

Subjects
Tufts University. Department of Biology.
Permanent URL
http://hdl.handle.net/10427/011077
ID: tufts:20549
To Cite: DCA Citation Guide