Forward genetic analysis of Toll-like receptor induced necroptosis and RIP1 kinase driven inflammation in wild-derived mice.Schworer, Stephen.
Abstract: The innate immune system, including the Toll-like receptor family, recognizes invading pathogens and activates the immune response through the induction of cytokines and other antimicrobial factors. The outcomes of TLR ligation and signaling extend beyond activation of gene expression to include programmed cell death. When virus-encoded caspase inhibitors block caspase activity or when c... read more
- Sackler School of Graduate Biomedical Sciences. Department of Immunology.
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