Genetic Characterization of ABL1 Inhibition and Regulation by the Tumor Suppressor PRDX1.

Salazar, Marcos.
2012

Abstract: The first portion of this thesis serves to further characterize the roles of PRDX1, mainly focusing on ABL1 regulation and oxidative stress. Our laboratory first discovered PRDX1 physically binds to c-ABL1 and suppresses its kinase activity. However, the interaction is not well defined. We found imatinib-resistant ABL1 kinase mutations, which are commonly seen in BCR-ABL1 of CML patients... read more

Subjects
Sackler School of Graduate Biomedical Sciences. Department of Genetics.
Permanent URL
http://hdl.handle.net/10427/011066
ID: tufts:20539
To Cite: DCA Citation Guide