Genetic Characterization of ABL1 Inhibition and Regulation by the Tumor Suppressor PRDX1.Salazar, Marcos.
Abstract: The first portion of this thesis serves to further characterize the roles of PRDX1, mainly focusing on ABL1 regulation and oxidative stress. Our laboratory first discovered PRDX1 physically binds to c-ABL1 and suppresses its kinase activity. However, the interaction is not well defined. We found imatinib-resistant ABL1 kinase mutations, which are commonly seen in BCR-ABL1 of CML patients... read more
- Sackler School of Graduate Biomedical Sciences. Department of Genetics.
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