BALANCE BETWEEN SHORT AND LONG ISOFORMS OF c-FLIP REGULATES Fas-MEDIATED APOPTOSIS IN VIVO.Ram, Daniel.
Abstract: cFLIP has been thought of to be a crucial regulator of apoptosis and necroptosis. This protein has been shown to also have roles in development as a deficiency in cFLIP leads to embryonic lethality in mice at day E10.5. cFlip is a Caspase 8 homologue that predominantly exists as two isoforms: cFLIPL (long) and cFLIPR (short) in mice. Humans have an additional short isoform: cFLIPS - whic... read more
- Sackler School of Graduate Biomedical Sciences. Department of Immunology.
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