Characterization of the Cell Wall Localization of Pneumolysin in Streptococcus pneumoniae.Price, Katherine.
Abstract: The bacterium Streptococcus pneumoniaeis a major causative agent of otitis media, pneumonia, bacteremia and meningitis. Pneumolysin (Ply), a member of the cholesterol-dependent cytolytic (CDC) pore-forming toxins, is produced by virtually all clinical isolates of S. pneumoniae, and strains deleted for the pneumolysin gene are severely attenuated in mouse models of colonization and infect... read more
- Sackler School of Graduate Biomedical Sciences. Department of Molecular Microbiology.
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