Inhibition of 2-methoxyestradiol glucuronidation by probenecid.

Qian, Yuli.
2015

Abstract: 2-Methoxyestradiol (2ME2), a metabolite of estradiol, has antitumor activity in vitro. However, potential clinical applicability has been limited by its low oral bioavailability. Glucuronidation via UDP-glucuronyl transferases (UGTs) is the major metabolic pathway that is responsible for the low oral bioavailability of 2ME2. In the present study, probenecid was evaluated in vitro as an i... read more

Subjects
Sackler School of Graduate Biomedical Sciences. Department of Pharmacology and Experimental Therapeutics.
Permanent URL
http://hdl.handle.net/10427/011038
ID: tufts:20512
To Cite: DCA Citation Guide