Calpain-1 Contributes to Platelet Hyperactivity and Pain Sensitivity in a Humanized Mouse Model of Sickle Cell Disease.

Nwankwo, Jennifer.

Abstract: Sickle cell disease (SCD) was the first genetic disorder for which a molecular mechanism was identified. SCD is caused by a glutamic acid to valine substitution in the sixth codon of the beta-globin gene, resulting in sickle hemoglobin, which polymerizes under low oxygen conditions to form sickle red blood cells (sRBCs). Reduced deformability of sickle RBCs contributes to blood vessel oc... read more

Sackler School of Graduate Biomedical Sciences. Department of Pharmacology and Experimental Therapeutics.
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