Phosphorylated ADAP promotes integrin-independent adhesion by stabilizing T cell receptor-induced SLP-76 microclusters.

Lewis, Juliana.
2012

Abstract: T cell activation occurs in the context of the immune synapse, a specialized adhesive junction that forms at the interface between T cells and antigen presenting cells. Signaling complexes that contain the SLP-76 adaptor protein form alongside the TCR at the immune synapse and effectively augment stable T cell contacts by activating integrins. These SLP-76 microclusters also bridge enzym... read more

Subjects
Sackler School of Graduate Biomedical Sciences. Department of Immunology.
Permanent URL
http://hdl.handle.net/10427/010995
ID: tufts:20466
To Cite: DCA Citation Guide