Forward Genetic Analysis of the CpG Hypo-response in Wild-derived MOLF/Ei Mice.

Moseman, Annie.

Abstract: Toll-like receptors (TLRs) are critical sensors in the recognition of microbial pathogens that activate the innate immune system and subsequently direct adaptive immune responses. CpG motif-containing oligodeoxynucleotides (CpG ODNs) mimic the immunostimulatory properties of bacterial DNA in innate and adaptive immune cells through toll-like receptor 9 (TLR9) signaling. Whether all cell ... read more

Sackler School of Graduate Biomedical Sciences. Department of Immunology.
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ID: tufts:20461
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