Components of the histone modifying CoREST/LSD1 complex regulate breast tumorigenesis and breast cell biology.Mazumdar, Sohini.
Abstract: Multiprotein complexes that regulate histone modifications and chromatin structure play critical roles in determining gene expression patterns important for cellular differentiation and neoplasia. This work explores the role of CoREST1 (corepressor of REST1) and LSD1 (Lysine specific demethylase 1) in breast cancer tumorigenesis and epithelial breast cell differentiation, respectively. C... read more
- Sackler School of Graduate Biomedical Sciences. Department of Genetics.
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