Critical roles for somatic hypermutation and TLR signaling in the development of B cell central tolerance.

McDonald, Gabrielle.
2016

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with a strong female bias. SLE pathogenesis is largely mediated by autoantibodies that form immune complexes, deposit in tissues, and cause inflammation. Autoantibody production is thought to be the result of somatic hypermutation (SHM) of Ig genes in antigen-activated B cells in the germinal center. However, we have rec... read more

Subjects
Sackler School of Graduate Biomedical Sciences. Department of Genetics.
Permanent URL
http://hdl.handle.net/10427/010965
ID: tufts:20438
To Cite: DCA Citation Guide