Adoptive Immunotherapy for Chronic Myeloid Leukemia in a Mouse Model.

Lu, Yi-Fen.
2011

Abstract: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by t(9;22) chromosomal translocation that creates the Philadelphia chromosome. The translocation encodes a constitutively active tyrosine kinase, BCR-ABL1, which turns a normal hematopoietic stem cell into a leukemic stem cell (LSC). BCR-ABL1 does not affect lineage differentiation. Therefore, CML is characterized cli... read more

Subjects
Sackler School of Graduate Biomedical Sciences. Department of Immunology.
Permanent URL
http://hdl.handle.net/10427/010952
ID: tufts:20425
To Cite: DCA Citation Guide