Adenomatous polyposis coli protein deletion leads to altered cochlear threshold sensitivity and ribbon synapse size.Hickman, Tyler.
Abstract: Normal hearing requires proper differentiation of afferent ribbon synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs), primary sensory neurons that carry acoustic information to the brain. Within individual IHCs, presynaptic ribbons show a size gradient with larger ribbons on the modiolar face and smaller ribbons on the pillar face. This morphological gradient is ... read more
- Sackler School of Graduate Biomedical Sciences. Department of Neuroscience.
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