MODULATION OF THE HOST UNFOLDED PROTEIN RESPONSE BY LEGIONELLA PNEUMOPHILA.Hempstead, Andrew D.
Abstract: Legionella pneumophila, the causative agent of Legionnaires disease, is a Gram-negative intracellular pathogen that replicates within alveolar macrophages during disease. The ability of L. pneumophila to replicate within a host cell is dependent on the Icm/Dot type IV secretion system (T4SS), which delivers Icm/Dot translocated substrates (IDTS) into the host cell cytosol. Many of these ... read more
- Sackler School of Graduate Biomedical Sciences. Department of Molecular Microbiology.
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