Inhibition of Cytochrome P450 Enzymes by Fruit Juices: In Vitro Effects, Clinical Relevance, and Therapeutic Implications.

Hanley, Michael.

Abstract: Drug interactions with dietary constituents are a concern for regulatory agencies, drug developers, clinicians, and patients. To date, much of the focus has been on grapefruit juice, which has been shown to inhibit enteric Cytochrome P450 (CYP) 3A and organic anion-transporting polypeptides. Consumption of blueberry juice and pomegranate juice has increased in recent years as the public ... read more

Sackler School of Graduate Biomedical Sciences. Department of Pharmacology and Experimental Therapeutics.
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