The AP2 clathrin adaptor protein complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans.Garafalo, Steven.
Abstract: AMPA-type ionotropic glutamate receptors (AMPARs) mediate the majority of excitatory neurotransmission in the mammalian CNS, and their abundance at synapses can directly alter synaptic strength. Alterations in synaptic strength are believed to underlie the mechanism by which we learn and encode memory, while aberrant glutamatergic signaling is thought to contribute to several neurodegene... read more
- Sackler School of Graduate Biomedical Sciences Department of Cell, Molecular and Developmental Biology.
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