Vav2 Inhibits T Cell Calcium Signaling by Activating Cdc42.

Fray, Michael A.
2016

Abstract: Vav proteins are tyrosine kinase-dependent guanine nucleotide exchange factors (GEFs) essential for a functional immune system. This family of proteins consists of three mammalian isoforms, Vav1, Vav2, and Vav3. Studies in mice have shown that knocking out all three of these isoforms leads to an almost complete loss in the number and function of T and B cells (Fujikawa et al., 2003), ser... read more

Subjects
Sackler School of Graduate Biomedical Sciences. Department of Immunology.
Permanent URL
http://hdl.handle.net/10427/010871
ID: tufts:20345
To Cite: DCA Citation Guide