Strategies for Understanding and Treating Osteoarthritis.

Gibson, Averi.

Abstract: Osteoarthritis (OA) is a disease characterized by articular cartilage degeneration. It causes chronic, debilitating pain, and as it is associated with aging and obesity, it is a continually expanding issue. Under OA conditions, mechanical stress and an increase in inflammatory cytokines such as IL-1 cause a disruption in joint homeostasis. As a result, metabolic and structural changes oc... read more

Sackler School of Graduate Biomedical Sciences. Department of Cell, Molecular & Developmental Biology.
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