Necl-5 Promotes Glioblastoma Pathogenesis by Enhancing MMP-2 Production and Protecting Cells from Fas-mediated Apoptosis.

Enloe, Brian.

Abstract: This thesis describes functions of the cell surface adhesion molecule Nectin-like molecule 5 (Necl-5) and its role in the pathogenesis of the deadly brain tumor glioblastoma (GBM). This thesis presents data showing that Necl-5 has two functions that have not been previously described. First, it promotes MMP-2 production, which is important for the invasive phenotype of GBM, and that MMP-... read more

Sackler School of Graduate Biomedical Sciences Department of Cell, Molecular and Developmental Biology.
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