Forward Genetic Analysis of the Toll-Like Receptor Response in Wild-Derived Mice.

Conner, James.

Abstract: Although a robust innate immune response is crucial to prevent fulminant pathogen dissemination, acute inflammatory mediators produced in this process can also potently damage host tissues. In light of these competing selective pressures, studies in evolutionarily divergent mouse strains that have faced challenges from unique pathogens and environments may reveal novel features of how th... read more

Sackler School of Graduate Biomedical Sciences. Department of Immunology.
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ID: tufts:20307
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