Genotype misclassification in genetic association studies of the rs1042522 TP53 (Arg72Pro) polymorphism: a systematic review of studies in breast, lung, colorectal, ovarian, and endometrial cancer.

Dahabreh, Issa.
2011

Abstract: Background: Genetic association studies in oncology often use tumor tissue as the source of genotyping material for cancer patients. Because tumors exhibit multiple somatic genetic aberrations, tumor-derived genetic material may not accurately represent the individual's constitutional genotype. Loss-of-heterozygosity (LOH) that preferentially affects one variant allele at a locus may aff... read more

Subjects
Sackler School of Graduate Biomedical Sciences. Department of Clinical and Translational Science.
Permanent URL
http://hdl.handle.net/10427/010827
ID: tufts:20300
To Cite: DCA Citation Guide