Investigation of the Biological Function of Fibroblast Activation Protein and its Potential as a Therapeutic Target in Cancer and Diabetes.

Coppage, Andrew.

Abstract: Fibroblast activation protein is an extracellular post-proline cleaving serine protease belonging to the S9 family of prolyl oligopeptidases. Other members of this family include DPPIV, DPP8, DPP9 and PREP, all of which share the relatively rare ability to cleave peptides after proline residues. This unique specificity suggests possible roles for these proteases in regulation of bioactiv... read more

Sackler School of Graduate Biomedical Sciences. Department of Biochemistry.
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ID: tufts:20295
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