Effect of Maternal Dietary B-Vitamin Intake on Offspring DNA Methylation Patterns, Gene Expression, Cytokinetics, and Intestinal Tumorigenesis in the Apc+/1638N Mouse Model.Ciappio, Eric.
Abstract: Epidemiological and laboratory data have repeatedly implicated one-carbon nutrients such as folate, riboflavin (vitamin B2), vitamin B6, and vitamin B12 as being protective against various cancers, most notably those of the colorectum. Deficiencies in one or all of these nutrients have been shown in a variety of experimental settings to lead to increases in genotoxic events associated wi... read more
- Gerald J. & Dorothy R. Friedman School of Nutrition Science and Policy.
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