Regulation of cartilage cell fate determination and homeostasis.

Cairns, Dana.

Abstract: We first studied the role of Shh in patterning the somite during early embryonic development. We found that differing levels of Shh signaling elicit differing responses from somitic cells: the lowest level of Shh signaling allows dermomyotomal gene expression, intermediate levels induce loss of dermomyotomal markers and activation of myogenic differentiation, and higher levels induce los... read more

Tufts University. Department of Biology.
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ID: tufts:20272
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