CYP2E1 Activity in Cisplatin Resistant Cancer Cells.

Babsail, Hussein.

Abstract: Cisplatin (CP) is an anticancer drug that kills tumor cells by interfering with DNA replication. One of the main obstacles limiting its use is intrinsic or acquired resistance development. Reactive oxygen species (ROS) have a known role in cancer cell apoptosis upon CP treatment. An excessive increase in ROS generation leads to other modes of cell death such as necrosis. Microsomal Cytoc... read more

Sackler School of Graduate Biomedical Sciences. Department of Pharmacology and Experimental Therapeutics.
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