Design, Synthesis, and Characterization of Potent and Specific Inhibitors for Dipeptidyl Peptidase II.

Arciprete, Michael.

Abstract: This paper reports on a systemic screen for potent and selective dipeptidyl peptidase (DPP) II inhibitors. The boronic acid derivative boroNorvaline (boroNva) was designated as the P1 position amino acid and a library of amino acids, both natural and synthetic, were coupled with boroNva to form dipeptide inhibitors. The inhibitors were tested against the members of the DPPIV activity and... read more

Sackler School of Graduate Biomedical Sciences. Department of Pharmacology and Experimental Therapeutics.
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