The Enzymatic Conversion of Phylloquinone to Menaquinone-4.

Al Rajabi, Ala.

Abstract: All forms of vitamin K share the naphthoquinone ring, but differ in the side chain. The naphthoquinone ring is the active site for the enzyme cofactor activity of vitamin K. Mammals have the ability to convert dietary phylloquinone into MK-4 and store the latter in specific tissues. This suggests that MK-4 plays a role beyond that of an enzyme cofactor. Several functions unique to MK-4 h... read more

Gerald J. & Dorothy R. Friedman School of Nutrition Science and Policy.
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