Discovering novel phenotypes with automatically inferred dynamic models: a partial melanocyte conversion in Xenopus.Levin, Michael.
Progress in regenerative medicine requires reverse-engineering cellular control networks to infer perturbations with desired systems-level outcomes. Such dynamic models allow phenotypic predictions for novel perturbations to be rapidly assessed in silico. Here, we analyzed a Xenopus model of conversion of melanocytes to a metastatic-like phenotype only previously observed in an all-or-none manner.... read more
- Regenerative medicine.
- Developmental biology.
- Computational biology.
- Tufts University. Department of Biology.
- Permanent URL
- Original publication
- Lobo, D. et al. Discovering novel phenotypes with automatically inferred dynamic models: a partial melanocyte conversion in Xenopus. Sci. Rep. 7, 41339; doi: 10.1038/srep41339 (2017).