Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions.

Nakamura, Daisy S.
Hollander, Judith M.
Uchimura, Tomoya.
Nielsen, Heber C.
Zeng, Li.
2017

Background: Inflammation is a major cause of cartilage destruction and leads to the imbalance of metabolic activities in the arthritic joint. Pigment epithelium-derived factor (PEDF) has been reported to have both pro- and anti-inflammatory activities in various cell types and to be upregulated in the arthritic joint, but its role in joint destruction is unclear. Our aim was to investigate the rol... read more

Permanent URL
http://hdl.handle.net/10427/010549
Original publication
Nakamura, Daisy, Judith M. Hollander, Tomoya Uchimura, Heber C. Nielsen, and Li Zeng. "Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions." BMC Musculoskeletal Disorders 18, no. 1 (12, 2017): 1-12.
ID: tufts:19536
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