ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis.

Romagnoli, Mathilde.
Mineva, Nora D.
Polmear, Michael.
Conrad, Catharina.
Srinivasan, Srimathi.
Loussouarn, Delphine.
Barillé-Nion, Sophie.
Georgakoudi, Irene.
Dagg, Áine.
Mcdermott, Edna W.
Duffy, Michael J.
Mcgowan, Patricia M.
Schlomann, Uwe.
Parsons, Maddy.
Bartsch, Jörg W.
Sonenshein, Gail E.
2014

The transmembrane metalloprotease‐disintegrin ADAM8 mediates cell adhesion and shedding of ligands, receptors and extracellular matrix components. Here, we report that ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue, especially in triple‐negative breast cancers (TNBCs) Furthermore, high ADAM8 levels predicted poor patient outcome. Consistently, ADAM8... read more

Subjects
Breast--Cancer.
Metastasis.
Tufts University. Department of Biomedical Engineering.
Genre
Permanent URL
http://hdl.handle.net/10427/010260
Original publication
Romagnoli, M., Mineva, N. D., Polmear, M., Conrad, C., Srinivasan, S., Loussouarn, D., . . . Sonenshein, G. E. (2014;2013;). ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis. EMBO Molecular Medicine, 6(2), 278-294. doi:10.1002/emmm.201303373.
ID: tufts:18923
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