Ultrasensitive single-genome sequencing: accurate, targeted, next generation sequencing of HIV-1 RNA.

Boltz, Valerie F.
Rausch, Jason.
Shao, Wei.
Hattori, Junko.
Luke, Brian.
Maldarelli, Frank.
Mellors, John W.
Kearney, Mary F.
Coffin, John M.
2016

Background: Although next generation sequencing (NGS) offers the potential for studying virus populations in unprecedented depth, PCR error, amplification bias and recombination during library construction have limited its use to population sequencing and measurements of unlinked allele frequencies. Here we report a method, termed ultrase... read more

Permanent URL
http://hdl.handle.net/10427/010227
Original publication
Boltz, Valerie, Jason Rausch, Wei Shao, Junko Hattori, Brian Luke, Frank Maldarelli, John W. Mellors, Mary F. Kearney, and John M. Coffin. "Ultrasensitive single-genome sequencing: accurate, targeted, next generation sequencing of HIV-1 RNA." Retrovirology 13, no. 1 (12, 2016): 1-17.
ID: tufts:18906
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